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Cell sex: a new look at cell fate studies
Author(s) -
Maselli Angela,
Matarrese Paola,
Straface Elisabetta,
Canu Silvia,
Franconi Flavia,
Malorni Walter
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.08-114348
Subject(s) - programmed cell death , cell fate determination , apoptosis , cell , microbiology and biotechnology , biology , demise , necrosis , pathogenesis , immunology , genetics , transcription factor , gene , political science , law
Cell death processes have been widely investigated in recent years in order to elucidate the different pathways involved in the complex machinery implicated in determining cell fate. Different forms of cell death have been described: Apart from the classical form of death known as necrosis, a well‐characterized traumatic injury of the cell, several additional forms of cell death have been identified. Of these, apoptosis has been characterized in the greatest detail. Defects in the mechanisms of cell demise (that is, an excess of or decrease in apoptosis) have been associated with the pathogenesis of a number of human diseases. Here we review some new aspects derived from recent insights into this field, particularly the hypothesis that cells of males and females could display several different features, including those determining their fate.—Maselli, A., Matarrese, P., Straface, E., Canu, S., Franconi, F., Malorni, W. Cell sex: a new look at cell fate studies. FASEB J . 23, 978–984 (2009)