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Maternal serotonin influences cardiac function in adult offspring
Author(s) -
Fiigny Céciie,
Fromes Yves,
Bonnin Philippe,
Darmon Michèie,
Bayard Elisa,
Launay Jean-Marie,
Côté Francine,
Mallet Jacques,
Vodjdani Guilan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.07-100743
Subject(s) - serotonergic , offspring , medicine , cardiac function curve , endocrinology , serotonin , phenotype , cardiomyopathy , heart failure , biology , pregnancy , genetics , receptor , gene
Using the Tph1 ‐invalidated mouse line, in which blood is depleted in serotonin (5‐hydroxytryp‐tamine, 5‐HT), we have demonstrated previously that maternal 5‐HT is required for normal embryonic development. Here, we address the issue of the influence of the maternal 5‐HT concentration on the cardiac function of the offspring as adults. We investigated the cardiac phenotype of Tph1 ‐invalidated mice born to Tph1 heterozygous and null mothers. Functionally, all mutants display a significant decrease of cardiac contractility, indicative of impaired left ventricular function. They exhibit progressive dilated cardiomyopathy and are unable to adapt appropriately to a pharmacological stress. Moreover, we show that the cardiopathy is more severe in adult Tph1 −/− mice born to homozygous mothers than to heterozygous mothers. Importantly, the severity of the cardiac phenotype is inversely correlated with the plasma 5‐HT concentration but not the whole‐blood 5‐HT concentration. Thus, plasma 5‐HT concentration may be a useful index of heart failure. These findings show that cardiac function, through the plasma 5‐HT concentration, is influenced by the maternal serotonergic status.—Fligny, C., Fromes, Y., Bonnin, P., Darmon, M., Bayard, E., Launay, J.‐M., Côté, F., Mallet, J., Vodjdani, G. Maternal serotonin influences cardiac function in adult offspring. FASEB J. 22, 2340–2349 (2008)