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Resolution of in flammation: state of the art, definitions and terms
Author(s) -
Serhan Charles N.,
Brain Sue D.,
Buckley Christopher D.,
Gilroy Derek W.,
Haslett Christopher,
O'Neill Luke A. J.,
Perretti Mauro,
Rossi Adriano G.,
Wallace John L.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.06-7227rev
Subject(s) - inflammation , endogeny , resolution (logic) , neuroscience , inflammatory response , field (mathematics) , process (computing) , medicine , immunology , computer science , biology , artificial intelligence , mathematics , pure mathematics , operating system
A recent focus meeting on Controlling Acute Inflammation was held in London, April 27–28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti‐inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. It is now evident that endogenous biochemical pathways activated during defense reactions can counter‐regulate inflammation and promote resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation‐associated diseases based on endogenous agonists of resolution.—Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., Wallace, J. L. Resolution of inflammation: state of the art, definitions and terms. FASEB J. 21, 325–332 (2007)