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Moderate consumption of Cabernet Sauvignon attenuates A� neuropathology in a mouse model of Alzheimer's disease
Author(s) -
Wang Jun,
Ho Lap,
Zhao Zhong,
Seror Ilana,
Humala Nelson,
Dickstein Dara L.,
Thiyagarajan Meenakshisundaram,
Percival Susan S.,
Talcott Stephen T.,
Maria Pasinetti Giulio
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.06-6281com
Subject(s) - neuropathology , wine , dementia , resveratrol , disease , medicine , chemistry , neuroscience , psychology , pharmacology , food science
Recent studies suggest that moderate red wine consumption reduces the incidence of Alzheimer's disease (AD) clinical dementia. Using Tg2576 mice, which model AD‐type amyloid beta‐protein (Aβ) neuropathology, we tested whether moderate consumption of the red wine Cabernet Sauvignon modulates AD‐type neuropathology and cognitive deterioration. The wine used in the study was generated using Cabernet Sauvignon grapes from Fresno, California, and was delivered to Tg2576 in a final concentration of ~6% ethanol. We found that Cabernet Sauvignon significantly attenuated AD‐type deterioration of spatial memory function and Aβ neuropathology in Tg2576 mice relative to control Tg2576 mice that were treated with either a comparable amount of ethanol or water alone. Chemical analysis showed the Cabernet Sauvignon used in this study contains a very low content of resveratrol (0.2 mg/L), 10‐fold lower than the minimal effective concentration shown to promote Aβ clearance in vitro . Our studies suggest Cabernet Sauvignon exerts a beneficial effect by promoting nonamyloidogenic processing of amyloid precursor protein, which ultimately prevents the generation of Aβ peptides. This study supports epidemiological evidence indicating that moderate wine consumption, within the range recommended by the FDA dietary guidelines of one drink per day for women and two for men, may help reduce the relative risk for AD clinical dementia.—Wang, J., Ho, L., Zhao, Z., Seror, I., Humala, N., Dickstein, D. L., Meenakshisundaram, T., Percival, S. S., Talcott, S. T., Pasinetti, G. M. Moderate consumption of Cabernet Sauvignon attenuates Aβ neuropathology in a mouse model of Alzheimer's disease. FASEB J. 20, 2313–2320 (2006)