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A brief history of RNAi: the silence of the genes
Author(s) -
Sen George L.,
Blau Helen M.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.06-6014rev
Subject(s) - rna interference , gene , silence , biology , function (biology) , computational biology , genetics , microbiology and biotechnology , rna , physics , acoustics
ABSTRACT The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.—Sen, G. L., Blau, H. M. A brief history of RNAi: the silence of the genes. FASEB J. 20, 1293–1299 (2006)