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Sialic acid binding immunoglobulin‐like lectins may regulate innate immune responses by modulating the life span of granulocytes
Author(s) -
Gunten Stephan,
Simon HansUwe
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.05-5401hyp
Subject(s) - siglec , innate immune system , biology , sialic acid , microbiology and biotechnology , programmed cell death , immunology , proinflammatory cytokine , tumor necrosis factor alpha , antibody , immune system , receptor , myeloid , innate lymphoid cell , apoptosis , inflammation , biochemistry
The regulation of cell death is a key element in building up and maintaining both innate and adaptive immunity. A critical role in this process plays the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor family of death receptors. Recent work suggests that sialic acid binding immunoglobulin (Ig) ‐like lectins (Siglecs) are also empowered to transmit death signals, at least into myeloid cells. Strikingly, death induction by Siglecs is enhanced when cells are exposed to proinflammatory survival cytokines. Based on these recent insights, we hypothesize that at least some members of the Siglec family regulate immune responses via the activation of caspase‐dependent and caspase‐independent cell death pathways.‐von Gunten, S., Simon, H.‐U. Sialic acid binding immunoglobulin‐like lectins (Siglecs) may regulate innate immune responses by modulating the life span of granulocytes. FASEB J. 20, 601–605 (2006)