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The constancy of the internal environment: proteins in plasma
Author(s) -
Rothman Stephen
Publication year - 2005
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.05-3922hyp
Subject(s) - exocytosis , endocytosis , vesicle , vesicular transport protein , chemistry , microbiology and biotechnology , biology , membrane , biochemistry , cell
The simple fact that there are normal concentrations of various proteins and peptides in blood has broad and surprising implications for how these molecules are released into and removed from the bloodstream by the cells of the body. If, as widely accepted, vesicle transport mechanisms such as exocytosis and endocytosis account for these events, then complex, presently unknown and seemingly unlikely mechanisms must exist to coordinate the rates of separate transport processes. The basis for this conclusion as well as the sole alternative method of transport, movement across permeable membranes, are discussed. Rothman, S. The constancy of the internal environment: proteins in plasma. FASEB J. 19, 1383–1388 (2005)