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Dopamine receptors set the pattern of activity generated in subthalamic neurons
Author(s) -
Baufreton J.,
Zhu Z.T.,
Garret M.,
Bioulac B.,
Johnson S. W.,
Taupig A. I.
Publication year - 2005
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.04-3401hyp
Subject(s) - dopamine , basal ganglia , neuroscience , dopaminergic , dopamine receptor , dopamine receptor d2 , subthalamic nucleus , receptor , dopamine receptor d1 , psychology , biology , parkinson's disease , medicine , central nervous system , disease , deep brain stimulation
ABSTRACT Information processing in the brain requires adequate background neuronal activity. As Parkinson's disease progresses, patients typically become akinetic; the death of dopaminergic neurons leads to a dopamine‐depleted state, which disrupts information processing related to movement in a brain area called the basal ganglia. Using agonists of dopamine receptors in the D1 and D2 families on rat brain slices, we show that dopamine receptors in these two families govern the firing pattern of neurons in the subthalamic nucleus, a crucial part of the basal ganglia. We propose a conceptual frame, based on specific properties of dopamine receptors, to account for the dominance of different background firing patterns in normal and dopamine‐depleted states. Baufreton, J., Zhu, Z.‐T., Garret, M., Bioulac, B., Johnson, S. W., Taupignon, A. I. Dopamine receptors set the pattern of activity generated in subthalamic neurons. FASEB J. 19, 1771–1777 (2005)