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Repetitive postprandial hyperglycemia increases cardiac ischemia/reperfusion injury: prevention by the α‐glucosidase inhibitor acarbose
Author(s) -
Frantz Stefan,
Calvillo Laura,
Tillmanns Jochen,
Elbing Inka,
Dienesch Charlotte,
Bischoff Hilmar,
Ertl Georg,
Bauersachs Johann
Publication year - 2005
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.04-2459fje
Subject(s) - acarbose , postprandial , medicine , ischemia , sucrose , placebo , diabetes mellitus , in vivo , endocrinology , pharmacology , chemistry , biochemistry , biology , alternative medicine , microbiology and biotechnology , pathology
Protective effects of the α‐glucosidase inhibitor acarbose have been reported for various diabetic complications. In the STOP‐NIDDM study, even patients without overt diabetes, but with impaired glucose tolerance, had a reduction in cardiovascular events when treated with acarbose. Therefore, we investigated the effect of repetitive postprandial hyperglycemia on the cardiac ischemia/reperfusion injury in vivo. Mice were treated daily by single applications of placebo, sucrose (4 g/kg body weight), or sucrose + acarbose (10 mg/kg body weight) by gavage for 7 days. Acarbose treatment significantly reduced the sucrose‐induced increase in plasma glucose concentration. Subsequently, animals underwent 30 min of ischemia by coronary artery ligation and 24 h of reperfusion in vivo. In the sucrose group, ischemia/reperfusion damage was significantly increased (infarct/area at risk, placebo vs. sucrose, 38.8±7.5% vs. 62.2±4.8%, P <0.05). This was prevented by acarbose treatment (infarct/area at risk 30.7±7.2%). While myocardial inflammation was similar in all groups, oxidative stress as indicated by a significant increase in lipid peroxides was enhanced in the sucrose, but not in the sucrose + acarbose group. In summary, repetitive postprandial hyperglycemia increases ischemia/reperfusion damage. This effect can be prevented by treatment with the α‐glucosidase inhibitor acarbose.