Premium
HLA‐G up‐regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells
Author(s) -
Lemaoult Joël,
Zafaranloo Kamélia,
Le Danff Caroline,
Carosella Edgardo D.
Publication year - 2005
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.04-1617fje
Subject(s) - immune system , antigen presenting cell , antigen , microbiology and biotechnology , human leukocyte antigen , antigen presentation , receptor , biology , chemistry , immunology , t cell , genetics
ABSTRACT The nonclassical HLA class I antigen HLA‐G is an inhibitory molecule involved in immune tolerance and immune escape. HLA‐G exerts its inhibitory functions via interaction with inhibitory receptors ILT2, ILT4, and KIR2DL4, differentially expressed by NK, T, and antigen‐presenting cells. Cells expressing HLA‐G and cells expressing its receptors are often found in the vicinity of each other, but the mechanisms responsible for this colocalization are still unknown. We report that ILT2, ILT3, ILT4 , and KIR2DL4 expression is up‐regulated by HLA‐G in antigen‐presenting cells, NK cells, and T cells. Because this up‐regulation seems not to require antigenic costimulation, it might precede an immune response. Functionally, up‐regulation of inhibitory receptors in immune cells before stimulation might increase their activation thresholds and participate in immune escape mechanisms.