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Hydrogen sulfide induces calcium waves in astrocytes
Author(s) -
Nagai Yasuo,
Tsugane Mamiko,
Oka JunIchiro,
Kimura Hideo
Publication year - 2004
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.03-1052fje
Subject(s) - long term potentiation , hippocampal formation , intracellular , biophysics , hydrogen sulfide , chemistry , calcium , astrocyte , gap junction , microbiology and biotechnology , neuroscience , biochemistry , biology , central nervous system , receptor , sulfur , organic chemistry
Hydrogen sulfide (H 2 S) modifies hippocampal long‐term potentiation (LTP) and functions as a neuromodulator. Here, we show that H 2 S increases intracellular Ca 2+ and induces Ca 2+ waves in primary cultures of astrocytes as well as hippocampal slices. H 2 S increases the influx of Ca 2+ and to a lesser extent causes the release from intracellular Ca 2+ stores. Ca 2+ waves induced by neuronal excitation as well as responses to exogenously applied H 2 S are potently blocked by La 3+ and Gd 3+ , inhibitors of Ca 2+ channels. These observations suggest that H 2 S induces Ca 2+ waves that propagate to neighboring astrocytes.