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Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs
Author(s) -
Lavitrano Marialuisa,
Smolenski Ryszard T.,
Musumeci Antonino,
Maccherini Massimo,
Slominska Ewa,
Florio Ernesto,
Bracco Adele,
Mancini Antonio,
Stassi Giorgio,
Patti Mariella,
Giovani Roberto,
Froio Alberto,
Simeone Felicetta,
Forni Monica,
Bacci Maria Laura,
D'Alise Giuseppe,
Cozzi Emanuele,
Otterbein Leo E.,
Yacoub Magdi H.,
Bach Fritz H.,
Calise Fulvio
Publication year - 2004
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.03-0996fje
Subject(s) - cardiopulmonary bypass , medicine , cardiology , phosphocreatine , anesthesia , reperfusion injury , cardiac surgery , carbon monoxide poisoning , adenosine , ischemia , energy metabolism , poison control , environmental health
Ischemia‐reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO‐treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.