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The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival
Author(s) -
Jackson Desmond N.,
Foster David A.
Publication year - 2004
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.03-0979rev
Subject(s) - cell growth , microbiology and biotechnology , activator (genetics) , cancer research , regulator , cell cycle , suppressor , biology , protein kinase a , kinase , cell , genetics , receptor , cancer , gene
Protein kinase Cδ (PKCδ) has been implicated both as a tumor suppressor and a positive regulator of cell cycle progression. PKCδ has also been reported to positively and negatively regulate apoptotic programs. This has led to conflicting hypotheses on the role of PKCδ in the control of cell proliferation and survival. Surprisingly PKCδ mice develop normally and are fertile indicating that PKCδ is not critical for normal cell proliferation during development. However PKCδ may play important roles in neoplastic cell proliferation. In this review we have summarized the apparent multifunctional properties of this enigmatic protein with regard to its role in the regulation of cell cycle progression and cell survival. It is proposed that PKCδ has both tumor suppressor and proliferation capabilities that can be recruited as a backup kinase for both gatekeeper tumor suppression and as an activator of the Ras/Raf/MEK/MAP kinase signaling pathway in cell proliferation.—Jackson D. N. Foster D. A. The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival.