Premium
Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases
Author(s) -
Straub Rainer H.,
Besedovsky Hugo O.
Publication year - 2003
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.03-0433hyp
Subject(s) - maladaptation , pathogenesis , immune system , homeostasis , endocrine system , immunology , disease , biology , neuroscience , inflammation , autoimmunity , rheumatoid arthritis , bioinformatics , medicine , hormone , genetics , endocrinology
The pathogenesis of chronic disabling inflammatory diseases (CDIDs) is poorly understood. Current concepts that focus on abnormalities of the immune system are, in our view, incomplete. Here we propose that chronic disruption of homeostasis through abnormal neuronal and endocrine host re‐ sponses to transient inflammatory reactions contributes to the appearance of CDIDs. Coordinated reactions of the supersystems (immune, nervous, endocrine, and reproductive) that maintain homeostasis have been evolutionarily conserved to respond to and eliminate foreign agents over a period of days to a few weeks. If the responses of these supersystems fail to return to normal after elimination of the pathogen, a continuous aggressive immune response is created; this situation can trigger development of CDIDs. Maladaptation of the supersystems during CDIDs has not been evolution‐ arily conserved but is nevertheless still prevalent be‐ cause a large proportion of these diseases tend to appear after the reproductive phase. We propose that this integrated systems hypothesis may permit better identification of a patient at risk or in the early stages of developing a CDID such as rheumatoid arthritis and enable more coordinated intervention than is presently attempted.—Straub, R. H., Besedovsky, H. O. Inte‐ grated evolutionary, immunological, and neuroendo‐ crine framework for the pathogenesis of chronic dis‐ abling inflammatory diseases. FASEB J. 17, 2176‐2183 (2003)