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Multiplex stress resistance in cells from long‐lived dwarf mice
Author(s) -
Murakami Shin,
Salmon Adam,
Miller Richard A.
Publication year - 2003
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.02-1092fje
Subject(s) - longevity , paraquat , biology , oxidative stress , microbiology and biotechnology , genetics , endocrinology , biochemistry
Mutations that extend nematode longevity by interference with IGF‐I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin‐derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H 2 O 2 , and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.