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Synthetic TGF‐β antagonist accelerates wound healing and reduces scarring
Author(s) -
Huang Jung San,
Wang YaoHorng,
Ling ThaiYen,
Chuang ShiowShuh,
Johnson Frank E.,
Huang Shuan Shian
Publication year - 2002
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.02-0103fje
Subject(s) - wound healing , granulation tissue , antagonist , medicine , transforming growth factor , contraction (grammar) , surgery , receptor
Wound healing consists of re‐epithelialization, contraction and formation of granulation and scar tissue. TGF‐β is involved in these events, but its exact roles are not well understood. Here we demonstrate that topical application of a synthetic TGF‐β antagonist accelerates re‐epithelialization in pig burn wounds (100% re‐epithelialization in antagonist‐treated wounds vs. ~ 70% reepithelialization in control wounds on postburn day 26) and reduces wound contraction and scarring in standard pig skin burn, pig skin excision and rabbit skin excision wounds. These results support the distinct roles of TGF‐β in the complex process of wound healing and demonstrate the feasibility of manipulating wound healing by TGF‐β antagonist.