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Programming effects of short prenatal exposure to cortisol
Author(s) -
DODIC MIODRAG,
HANTZIS VICKY,
DUNCAN JHODIE,
REES SANDRA,
KOUKOULAS IRENE,
JOHNSON KELLI,
WINTOUR E. MARELYN,
MORITZ KAREN
Publication year - 2002
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.01-1045com
Subject(s) - offspring , gestation , prenatal stress , endocrinology , blood pressure , medicine , hippocampus , fetus , pregnancy , prenatal development , physiology , biology , genetics
Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of this study were twofold: 1) to see whether cortisol treatment administered to the ewe for 2 days at 27 days of gestation (term ~150 days) resulted in high blood pressure in offspring; 2) to study the effect of the same treatment on gene expression in the brain at 130 days of gestation and in lambs at 2 months of age. Mean arterial pressure was significantly higher in the adult female and male offspring of sheep treated with cortisol than in the control group (females: 89±2 mmHg vs. 81±2; P <0.05 and males: 102±4 mmHg vs. 91±3; P <0.05). Prenatal cortisol treatment led to up‐regulation of angiotensinogen, AT 1 , MR, and GR mRNA in the hippocampus in fetuses at 130 days of gestation but not in the animals at 2 months of age. This is the first evidence that short prenatal exposure to cortisol programmed high blood pressure in the adult female and male offspring of sheep. Altered gene expression in the hippocampus could have a significant effect on the development of the hippocampus, and on postnatal behavior.—Dodic, M., Hantzis, V., Duncan, J., Rees, S., Koukoulas, I., Johnson, K., Wintour, E. M., Moritz, K. Programming effects of short prenatal exposure to cortisol. FASEB J. 16, 1017–1026 (2002)