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MHC and MHC‐related proteins as pleiotropic signal molecules
Author(s) -
Ojcius David M.,
Delarbre Christiane,
Kourilsky Philippe,
Gachelin Gabriel
Publication year - 2002
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.01-0758com
Subject(s) - major histocompatibility complex , microbiology and biotechnology , mhc class i , biology , signal transduction , function (biology) , mhc restriction , cd74 , antigen , immunology
Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHC‐related molecules have a much more varied function in the body. Many of these molecules are involved in pleiotropic interactions with other proteins, which initiate signal transduction cascades and contribute to cellular and tissue homeostasis.—Ojcius, D. M., Delarbre, C., Kourilsky, P., Gachelin, G. MHC and MHC‐related proteins as pleiotropic signal molecules. FASEB J. 16, 202–206 (2001)