Open AccessNeural regulations of the tumor microenvironment
Author(s) -
Restaino Anthony C.,
Vermeer Paola D.
Publication year - 2022
Publication title -
faseb bioadvances
Language(s) - English
Resource type - Journals
ISSN - 2573-9832
DOI - 10.1096/fba.2021-00066
Subject(s) - tumor microenvironment , stromal cell , immune system , neuroscience , biology , cancer , disease , population , pathology , medicine , cancer research , immunology , environmental health
The identification of nerves in the tumor microenvironment has ushered in a new area of research in cancer biology. Numerous studies demonstrate the presence of various types of peripheral nerves (sympathetic, parasympathetic, sensory) within the tumor microenvironment; moreover, an increased density of nerves in the tumor microenvironment correlates with worse prognosis. In this review, we address the current understanding of nerve‐mediated alterations of the tumor microenvironment and how they impact disease through a variety of processes, including direct nerve‐cancer cell communication, alteration of the infiltrative immune population, and alteration of stromal components.