Open AccessEmerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion
Author(s) -
Leidal Andrew M.,
Debnath Jayanta
Publication year - 2021
Publication title -
faseb bioadvances
Language(s) - English
Resource type - Journals
ISSN - 2573-9832
DOI - 10.1096/fba.2020-00138
Subject(s) - autophagy , secretion , biogenesis , microbiology and biotechnology , extracellular , cytosol , microvesicles , intracellular , extracellular vesicle , biology , chemistry , biochemistry , gene , microrna , enzyme , apoptosis
Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via lysosomal pathways. However, accumulating evidence also supports roles for autophagy‐related genes (ATGs) in non‐degradative processes including cellular secretion. Here, we review emerging roles for the autophagy machinery in regulating extracellular vesicle loading and secretion and discuss how functional coupling of these pathways may impact normal physiology and disease.