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Transcriptional regulation in the yeast GAL gene family: a complex genetic network
Author(s) -
Lohr D.,
Venkov P.,
Zlatanova J.
Publication year - 1995
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.9.9.7601342
Subject(s) - yeast , genetics , gene , gene regulatory network , biology , computational biology , gene expression
Regulation of the GAL structural genes in the yeast Saccharomyces cerevisiae is implemented by the products of GAL‐specific ( GAL4 , GAL80 , GAL3 ) and general ( GAL11 , SWI1 , 2, 3 , SNF5 , 6, numerous glucose repression) genes. Recent work has 1 ) yielded significant new insights on the DNA binding and transcription activation/Gal80 protein binding functions of the Gal4 activator protein, 2 ) described the characterization of purified Gal4 protein‐Gal80 protein complexes, 3 ) deconvoluted the multiple and complex glucose repression pathways acting on GAL genes, 4 ) suggested a new mechanism for the Gal3 protein‐mediated induction of GAL structural gene expression, 5 ) introduced Gall protein, a structural gene product, into the regulation scheme, and 6 ) extended our already substantial understanding of GAL regulatory gene control. The mechanisms which control structural and regulatory gene expression in the GAL family are compared and GAL structural/regulatory gene chromatin structure is discussed.—Lohr, D., Venkov, P., Zlatanova, J. Transcriptional regulation in the yeast GAL gene family: a complex genetic network. FASEB J. 9, 777‐787 (1995)