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Chloride channels: a state of flux
Author(s) -
Valverde Miguel A.,
Hardy Simon P.,
Sepúlveda Francisco V.
Publication year - 1995
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.9.7.7737459
Subject(s) - chloride channel , chloride , ion channel , chemistry , ion transporter , biophysics , cystic fibrosis , membrane potential , microbiology and biotechnology , biochemistry , membrane , biology , medicine , receptor , organic chemistry
Chloride channels play important functions in different aspects of cell physiology including volume regulation, transepithelial ion transport and stabilization of membrane potential. In recent years the molecular identity of the chloride channels defective in cystic fibrosis and myotonia congenita has been elucidated, highlighting the importance of anion‐selective channels in cell and tissue function. Concurrently, several proteins have been identified as chloride channels along with proteins that possess channel regulatory behavior. Novel interactions with more potent pharmacological compounds have been reported with different chloride channels. This burgeoning field of interest is reviewed.—Valverde, M. A., Hardy, S. P., Sepúlveda, F. V. Chloride channels: a state of flux. FASEB J. 9, 509–515 (1995)