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Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation
Author(s) -
Allende Jorge E.,
Allende Catherine C.
Publication year - 1995
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.9.5.7896000
Subject(s) - casein kinase 1 , casein kinase 2 , ask1 , cyclin dependent kinase 2 , cyclin dependent kinase , kinase , cyclin dependent kinase complex , microbiology and biotechnology , casein kinase 2, alpha 1 , biochemistry , mitogen activated protein kinase kinase , protein kinase a , cyclin dependent kinase 9 , protein subunit , cyclin dependent kinase 3 , map2k7 , c raf , biology , chemistry , cell cycle , cell , gene
Protein kinase CK2 (also known as casein kinase II) is a ubiquitous eukaryotic ser/thr protein kinase present in the nucleus and cytoplasm. CK2 is known to phosphorylate more than 100 substrates, many of which are involved in the control of cell division and in signal transduction. The review centers on the structure and function of CK2 α and β subunits and on the regulation of its activity, a topic that remains to be elucidated. An analogy is drawn between CK2 and the cyclin‐dependent kinases (cdks); both types of protein kinases share many substrates and are activated by regulatory subunits.—Allende, J. E., Allende, C. C. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation. FASEB J. 9, 313–323 (1995)