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Mechanisms of calcium oscillations and waves: a quantitative analysis
Author(s) -
Sneyd James,
Keizer Joel,
Sanderson Michael J.
Publication year - 1995
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.9.14.7589988
Subject(s) - inositol , intracellular , nonlinear system , inositol trisphosphate , physics , calcium , inositol trisphosphate receptor , biological system , biophysics , receptor , chemistry , biology , biochemistry , organic chemistry , quantum mechanics
Oscillations and waves of increased intracellular free calcium concentration ([Ca 2+ ],) are observed in a wide range of cell types. Because of their inherent nonlinear nature and the consequent unreliability of intuitive approaches, mathematical modeling has an important role to play in the study of these phenomena. One important class of oscillations and waves is dependent on the presence of inositol (l, 4, 5)‐trisphosphate (IP3), which releases Ca 2+ from internal stores via the IP3 receptor/Ca 2+ channel. With the minimum possible mathematical formalism, we review mechanistic models for IP3‐de‐ pendent Ca 2+ oscillations and waves. These models are based on the regulation of the IP3 receptor by both IP3 and Ca 2+ , and incorporate experimental data on the steady‐state and kinetic properties of the receptor. The extension of the models to describe intracellular and intercellular Ca 2+ waves is considered.—Sneyd, J., Keizer, J., Sanderson, M. J. Mechanisms of calcium oscillations and waves: a quantitative analysis. FASEB J . 9, 1463‐1472 (1995)