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Actions of anesthetics on ligand‐gated ion channels: role of receptor subunit composition
Author(s) -
Harris R. Adron,
Mihic S. John,
DildyMayfield Jo Ellen,
Machu Tina K.
Publication year - 1995
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.9.14.7589987
Subject(s) - kainate receptor , ion channel , protein subunit , ampa receptor , chemistry , ligand gated ion channel , receptor , gabaa receptor , anesthetic , pharmacology , glycine receptor , gamma aminobutyric acid receptor subunit alpha 1 , nmda receptor , biochemistry , biophysics , glycine , biology , amino acid , g alpha subunit , medicine , anesthesia , gene
Molecular cloning of cDNAs coding for ligand‐gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions. Many laboratories have used these techniques recently to study actions of agents that produce general anesthesia. We review the effects of volatile and intravenous anesthetics on recombinant GABA a , glycine, AMPA, kainate, NMDA, and 5HT3 receptors. Evidence for and against specific ligand‐gated ion channel subunits as targets responsible for anesthesia or the side effects of anesthetic agents is discussed for each type of receptor. Subunit specific actions of some of the agents suggest that construction and testing of certain chimeric receptor subunits may be useful for defining the amino acid sequences responsible for anesthetic actions.—Harris, R. A., Mihic, S. J., Dildy‐Mayfield, J. E., Machu, T. K. Actions of anesthetics on ligandgated ion channels: role of receptor subunit composition. FASEBJ. 9, 1454‐1462 (1995)