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The RNA polymerase II elongation complex
Author(s) -
Aso Teuiro,
Conaway Joan Weuky,
Conaway Ronald C.
Publication year - 1995
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.9.14.7589983
Subject(s) - rna polymerase ii , transcription (linguistics) , transcription factor ii d , polymerase , rna polymerase i , rna polymerase , rna polymerase ii holoenzyme , transcription factor ii f , biology , microbiology and biotechnology , elongation , rna , genetics , gene , gene expression , promoter , linguistics , philosophy , materials science , ultimate tensile strength , metallurgy
The initiation stage of transcription by RNA polymerase II has long been regarded as the primary site for regulation of eukaryotic gene ex‐pression. Nevertheless, a growing body of evidence reveals that the RNA polymerase II elongation com‐plex is also a major target for regulation. Biochelmical studies are implicating an increasing number of transcription factors in the regulation of elongation, and these transcription factors are being found to function by a diverse collection of mechanises. Moreover, unexpected features of the structure and catalytic mechanism of RNA polymerase II are forcing a reconsideration of long‐held views on the jnechanics of some of the most basic aspects of polymerase function. In this review, we will describe recent insights into the structures and functions of RNA polymerase II and the transcription factors that control its activity during the elongation stage of eukaryotic messenger RNA synthesis.—Aso, T., Conaway, J. W., Conaway, R. C. The RNA polpnerase II elongation complex. FASEB J. 9, 1419‐1428(1995)