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A structural view of CD4 and CD8
Author(s) -
Leahy Daniel J.
Publication year - 1995
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.9.1.7821755
Subject(s) - cd8 , microbiology and biotechnology , mhc class i , chemistry , major histocompatibility complex , transmembrane protein , transmembrane domain , t cell , extracellular , mhc class ii , biology , antigen , biochemistry , immune system , immunology , membrane , receptor
CD4 and CD8 are cell‐surface glycoproteins that participate in molecular complexes involved in both T cell development and antigen recognition by T cells, CD4 and CDS interact with nonpolymorphic regions of class 11 and class I major histocompatibility complex (MHC) molecules, respectively, and these interactions result in increased intercellular adhesion and enhanced stimulation of T cells. A src‐like tyrosine kinase, p56 lck , is associated with the cytoplasmic domain of both CD4 and CD8 and may be involved in transmembrane signaling. Crystal structures of extracellular regions of CD4 and CDS have been determined and have provided a basis for understanding and probing CD4 and CDS function. The structures of CD4 and CD8 are reviewed here, along with the implications of these structures for CD4 and CD8 function.—Leahy, D. J. A structural view of CD4 and CD8. FASEB J. 9, 17‐25 (1995)