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Pharmacological regulation of AP‐1 transcription factor DNA binding activity 1
Author(s) -
Pennypacker Keith R.,
Hong JauShyong,
McMillian Michael K.
Publication year - 1994
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.8.8.8181665
Subject(s) - transcription factor , dna , transcription (linguistics) , microbiology and biotechnology , dna binding protein , general transcription factor , biology , dna binding site , response element , activating transcription factor 2 , sp3 transcription factor , promoter , gene expression , genetics , gene , enhancer , linguistics , philosophy
The AP‐1 transcription factor family consists of two groups of proteins, fos‐related antigens (fra) and jun proteins. These transcription factors are usually expressed at low basal levels but they can be dramatically induced in a variety of cell types by many different stimuli, in which the quantity of AP‐1 transcription factor and the DNA binding activity also rise. The quantity and DNA binding activity of transcription factors are not always at low levels. For example, early in brain development a high basal expression of AP‐1 DNA binding activity exists. Similarly, adult rat adrenal gland contains high levels of AP‐1 DNA binding activity whose regulation appears to be through post‐translational modification (i.e., phosphorylation). Thus, AP‐1 DNA binding activity is modulated in a developmental and tissue‐specific manner.—Pennypacker, K. R., Hong, J.‐S., McMillian, M. K. Pharmacological regulation of AP‐1 transcription factor DNA binding activity. FASEB J. 8: 475‐478; 1994.