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The cyclin‐dependent protein kinases and the control of cell division
Author(s) -
Dorée Marcel,
Galas Simon
Publication year - 1994
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.8.14.7958616
Subject(s) - cyclin dependent kinase , microbiology and biotechnology , cyclin a , cyclin dependent kinase 1 , cell cycle , cyclin , dna replication , polo like kinase , origin recognition complex , kinase , licensing factor , maturation promoting factor , phosphorylation , eukaryotic dna replication , biology , chemistry , biochemistry , cell , dna
A few years after the identification of cyclin B‐cdc2 kinase as the universal factor that controls onset of M‐phase in eukaryotic cells, MPF (M‐phase promoting factor), it became evident that all transitions of the cell cycle are controlled through phosphorylation of specific targets due to changes in the activity of a variety of cyclin‐dependent kinases (cdks). These transitions include conversion of quiescent cells to a state of active proliferation, commitment to DNA replication, initiation of DNA replication, and entry into and exit from mitosis. Changes in the activity of cdks along the cell cycle depend not only on their association with a variety of cycling (including G1/S and G2/M cyclins) and on posttranslational modifications by phosphorylation‐dephosphorylation reactions, but also on specific protein inhibitors and on protein degradation.—Dorée, M., Galas, S. The cyclin‐dependent protein kinases and the control of cell division. FASEB J. 8, 1114‐1121 (1994)