Premium
Role of nutritional fatty acid and L‐carnitine in the final outcome of thioacetamide hepatotoxicity 1
Author(s) -
Chanda Sanjay,
Mehendale Harihara M.
Publication year - 1994
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.8.13.7926372
Subject(s) - thioacetamide , carnitine , chemistry , outcome (game theory) , fatty acid , medicine , biochemistry , economics , mathematical economics
Male Sprague‐Dawley rats ( n = 10/group) were fully protected from a lethal dose (600 mg/kg, i.p.) of thioacetamide by adding 8% (w/w) palmitic acid to the diet and l ‐carnitine (2 mg/ml) to drinking water for the previous 7 days. Supplements of palmitic acid or l ‐carnitine alone did not confer protection. Liver injury induced by thioacetamide peaked between 36 and 48 h in both control and supplemented rats. Liver damage regressed thereafter in supplemented rats but progressed in control rats. Immunohistochemical and histopathological observations confirmed biochemical indicators of liver damage. Thus, hepatic tissue repair after thioacetamideinduced tissue injury seems to be stimulated by supplements of fatty acids together with l ‐carnitine, a mitochondrial transfer agent. The extent to which nutritional supplements may aid in inducing the recovery of liver from injury caused by other hepatotoxic agents remains to be explored.—Chanda, S., Mehendale, H. M. Role of nutritional fatty acid and L‐carnitine in the final outcome of thioacetamide hepatotoxicity. FASEB J. 8: 1061‐1068; 1994.