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Glucose transporter proteins in brain
Author(s) -
Maher Frances,
Vannucci Susan J.,
Simpson Ian A.
Publication year - 1994
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.8.13.7926364
Subject(s) - glut3 , glucose transporter , glut1 , transporter , glucose transporter type 1 , gene isoform , blood–brain barrier , microglia , biology , biochemistry , glucose uptake , isolated brain , chemistry , microbiology and biotechnology , neuroscience , central nervous system , endocrinology , gene , insulin , immunology , inflammation
Glucose is the principal energy source for the mammalian brain. The presence of glucose transport proteins is essential to supply glucose to the neurons and glia within the brain. At least three glucose transporter isoforms have now been identified, and are thought to play a significant role, in the brain. This review describes our current understanding of cell‐specific glucose transporter expression in brain, which includes GLUT1 (55‐kDa form) present at a high concentration at the blood‐brain barrier as well as in parenchymal cells (45‐kDa form), most likely in astrocytes, GLUT3 expressed in neurons, and GLUT5 in microglia. We discuss some potential implications of this glucose transporter heterogeneity for cerebral metabolic activity.—Maher, F., Vannucci, S. J., Simpson, I. A. Glucose transporter proteins in brain. FASEB J. 8: 1003‐1011; 1994.