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Fibrogenic cytokines and connective tissue production
Author(s) -
Kovacs Elizabeth J.,
Dipietro Luisa A.
Publication year - 1994
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.8.11.7520879
Subject(s) - connective tissue , extracellular matrix , microbiology and biotechnology , pathogenesis , extracellular , chemotaxis , chemistry , secretion , immunology , biology , pathology , medicine , biochemistry , receptor
The pathogenesis of fibrotic disorders is similar regardless of the tissues involved. Inflammatory leukocytes infiltrate the site triggered by chemotactic and activating mediators. This is followed by the elaboration of cytokines that directly and indirectly induce the proliferation of fibroblasts and endothelial cells and the deposition of extracellular matrix (ECM). In the absence of inhibitory signals, the continued production of these mediators sustains the connective tissue accumulation, which results in permanent alteration in tissue structure and function.— Kovacs, E. J., DiPietro, L. A. Fibrogenic cytokines and connective tissue production. FASEB J. 8: 854‐861; 1994.