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Site‐specific genetic recombination: hops, flips, and flops
Author(s) -
Sadowski Paul D.
Publication year - 1993
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.7.9.8392474
Subject(s) - recombination , flp frt recombination , genetic recombination , site specific recombination , biology , genetics , homologous recombination , cre lox recombination , dna , recombinase , gene , transgene , genetically modified mouse
Genetic recombination plays a key role in the life of organisms as diverse as bacteriophages and humans. Contrary to our idea that chromosomes are stable structures, studies of recombination over the past few decades have shown that in fact DNA replicons are remarkably plastic, undergoing frequent recombination‐induced rearrangements. This review summarizes our recent knowledge of the biochemistry of the two major classes of site‐specific recombination: 1 ) transpositional recombination, and 2 ) conservative site‐specific recombination.—Sadowski, P. D. Site‐specific genetic recombination: hops, flips, and flops. FASEB J. 7: 760‐767; 1993.