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Role of the CD45 tyrosine phosphatase in signal transduction in the immune system
Author(s) -
Koretzky Gary A.
Publication year - 1993
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.7.5.8462784
Subject(s) - protein tyrosine phosphatase , signal transduction , immune system , phosphatase , microbiology and biotechnology , chemistry , biology , immunology , phosphorylation
CD45, a family of hematopoietic cell specific surface antigens, is the best characterized protein tyrosine phosphatase described to date. Considerable evidence from a number of laboratories suggests that surface expression of this molecule is required for normal signaling events to occur in T lymphocytes, B lymphocytes, and natural killer cells. In this paper, data supporting this contention are reviewed and a model proposing how CD45 may exert its regulatory function on signal transduction via the T cell antigen receptor is presented.— Koretzky, G. A. Role of the CD45 tyrosine phosphatase in signal transduction in the immune system. FASEB J. 7: 420‐426; 1993.