Premium
Is dehydroepiandrosterone an antiobesity agent?
Author(s) -
Berdanier Carolyn D.,
Parente John A.,
McIntosh Michael K.
Publication year - 1993
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.7.5.8462783
Subject(s) - dehydroepiandrosterone , endocrinology , medicine , lipogenesis , hormone , chemistry , lipid metabolism , biology , androgen
The steroid hormone intermediate, DHEA, has been proposed as a therapeutic agent for the treatment of obesity. Its effects on lipogenesis, substrate cycling, peroxisome proliferation, mitochondrial respiration, protein synthesis, and thyroid hormone function have been reported. The results of these studies suggest that the antiobesity function of DHEA is not simply one of inhibiting fat synthesis and deposition but is one of affecting a number of pathways that contribute to the maintenance of the isoenergetic state rather than the promotion of positive energy balance.— Berdanier, C. D., Parente, J. A., Jr., McIntosh, M. K. Is dehydroepiandrosterone an antiobesity agent? FASEB J. 7: 414‐419; 1993.