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Intracellular cyclic GMP receptor proteins
Author(s) -
Lincoln Thomas M.,
Cornwell Trudy L.
Publication year - 1993
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.7.2.7680013
Subject(s) - intracellular , microbiology and biotechnology , phosphodiesterase 3 , pde10a , extracellular , phosphorylation , cgmp dependent protein kinase , chemistry , second messenger system , protein kinase a , cyclic nucleotide , receptor , phosphodiesterase , protein phosphorylation , signal transduction , biochemistry , biology , mitogen activated protein kinase kinase , nucleotide , gene , enzyme
Cyclic GMP is recognized as an important intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP‐dependent protein kinases, cGMP‐regulated ion channels, and cGMP‐regulated cyclic nucleotide phosphodiesterases. This means that cGMP can alter cell function through protein phosphorylation or through mechanisms not directly related to protein phosphorylation. Cyclic GMP appears to regulate a number of intracellular processes, such as vascular smooth muscle relaxation and neutrophil activation, through these receptor proteins in the cell. It is also becoming clear that the localization of these cGMP receptor proteins in the cell is an important factor in the regulation of cell function by cGMP.— Lincoln, T. M.; Cornwell, T. L. Intracellular cyclic GMP receptor proteins. FASEB J. 7: 328‐338; 1993.