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HIV binding to its receptor creates specific epitopes for the CD4/gp120 complex
Author(s) -
Gershoni Jonathan M.,
Denisova Galina,
Raviv Daphna,
Smorodinsky Nechama I.,
Buyaner Diana
Publication year - 1993
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.7.12.7690724
Subject(s) - epitope , monoclonal antibody , virology , human immunodeficiency virus (hiv) , biology , receptor , syncytium , antibody , chemistry , immunology , genetics
Effective vaccines against the human immunodeficiency virus (HIV) must cope with the genetic variation of the viral envelope (gp120) to combat or prevent acquired immunodeficiency syndrome (AIDS). Here we describe novel epitopes that are accentuated when gp120 complexes with its receptor (CD4). The presentation of these epitopes results through conformational rearrangements in the CD4/gp120 complex. Monoclonal antibodies directed to these epitopes inhibit syncytium formation, thus indicating the potential use of these epitopes as subunit vaccines.—Gershoni, J. M., Denisova, G., Raviv, D., Smorodinsky, N. I., Buyaner, D. HIV binding to its receptor creates specific epitopes for the CD4/gp120 complex. FASEB J. 7: 1185‐1187; 1993.