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Intracellular parasitism of Legionella and signaling in eukaryotic cells
Author(s) -
Belyi Yura F.
Publication year - 1993
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.7.11.8370469
Subject(s) - intracellular , intracellular parasite , signal transduction , legionella pneumophila , facultative , microbiology and biotechnology , virulence , biology , parasitism , legionella , bacteria , host (biology) , genetics , ecology , gene
In this review the phenomenon of anti‐bacterial activity of phagocytes and its relationship to the general system of signal transduction in eukaryotic cells is examined. Data are reviewed that support the hypothesis that interference in transduction of regulatory signals during microbial invasion could be caused by specific bacterial products and lead to an inadequate bactericidal response, and hence multiplication of the bacteria in a host. In this connection, information concerning virulence factors of the facultative intracellular parasite Legionella is discussed.—Belyi, Y. F. intracellular parasitism of Legionella and signaling in eukaryotic cells. FASEB J. 7: 1011‐1015; 1993.