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ATP‐dependent bacterial transporters and cystic fibrosis: analogy between channels and transporters
Author(s) -
Ames Giovanna FerroLuzzi,
Lecar Harold
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.9.1377140
Subject(s) - cystic fibrosis , transporter , analogy , atp binding cassette transporter , chemistry , biology , microbiology and biotechnology , biochemistry , genetics , gene , philosophy , linguistics
The traffic ATPases superfamily includes known transporters, both prokaryotic and eukaryotic, including the medically important proteins, P‐glycoprotein, and the cystic fibrosis gene product (CFTR), which is known to be a Cl – channel. The structure and mechanism of action of the best‐studied members of the superfamily, the periplasmic permeases, are described and related to that of CFTR and eukaryotic traffic ATPases in general. The contention is put forward that the distinction between the architecture and mechanisms of action of channels and transporters is blurred.— Ames, G. F.‐L., Lecar, H. ATP‐dependent bacterial transporters and cystric fibrosis: analogy between channels and transporters. FASEB J. 6: 2660‐2666; 1992.