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Signal transduction from cell surface to nucleus in development and disease
Author(s) -
Karin Michael
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.8.1317309
Subject(s) - nucleus , signal transduction , surface (topology) , cell , microbiology and biotechnology , neuroscience , chemistry , biology , mathematics , biochemistry , geometry
Recent studies indicate that extracellular signals affect cell proliferation and differentiation by modulating transcription factor activity via protein phosphorylation cascades. This review discusses the basic outline of the eukaryotic signal transduction systems used to transmit information from the cell surface to the transcriptional machinery in the nucleus. Several examples that illustrate how these pathways control cell proliferation, differentiation and development are discussed.—Karin, M. Signal transduction from cell surface to nucleus in development and disease. FASEB J. 6: 2581‐2590; 1992.