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The Src family of tyrosine protein kinases in hemopoietic signal transduction
Author(s) -
Bolen Joseph B.,
Rowley R. Bruce,
Spana Carl,
Tsygankov Alexander Y.
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.15.1281458
Subject(s) - proto oncogene tyrosine protein kinase src , tyrosine protein kinase csk , sh3 domain , receptor tyrosine kinase , signal transduction , biology , tyrosine kinase , microbiology and biotechnology , cdc37 , kinase , protein tyrosine phosphatase , mitogen activated protein kinase , extracellular signal regulated kinases
The Src family of tyrosine protein kinases represent an expanding class of closely related intracellular enzymes that participate in the signal transduction pathways of a variety of surface receptors. One of the more surprising aspects of the information relating Src protein kinases to receptor signaling is the apparent diversity of receptor types with which the Src‐related enzymes are reported to interact physically or functionally. Traditional biochemical and genetic approaches have yielded much information regarding the interactions between the Src tyrosine protein kinases and other cellular proteins in defined cell types, and emerging technologies, most notably homologous recombination in embryonal stem cells to achieve gene “knockouts,” are providing new insights into the participation of the Src‐related gene products in signal transduction and development.— Bolen, J. B., Rowley, R. B., Spana, C., Tsygankov, A. Y. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 6: 3403‐3409; 1992.