Premium
Transcription by RNA polymerase II: initiator‐directed formation of transcription‐competent complexes 1
Author(s) -
Weis Lisa,
Reinberg Danny
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.14.1426767
Subject(s) - transcription factor ii d , general transcription factor , rna polymerase ii , transcription factor ii b , transcription factor ii f , transcription factor ii a , transcription (linguistics) , transcription factor ii e , promoter , rna polymerase ii holoenzyme , microbiology and biotechnology , response element , tata box , rna polymerase , e box , taf2 , biology , chemistry , rna , genetics , gene expression , gene , linguistics , philosophy
Studies of transcription by RNA polymerase II have revealed two promoter elements, the TATA motif and the initiator (Inr), capable of directing specific transcription initiation. Although binding to the TATA motif by one of the components of the transcription machinery has been shown to be the initial recognition step in transcription complex formation, many promoters that lack a traditional TATA motif have recently been described. In such TATA‐less promoters, the Inr element is critical in positioning RNA polymerase II. Various Inr elements have been described and classified according to sequence homology. These Inr elements are recognized specifically by Inr‐binding proteins. Interaction between these Inr‐binding proteins and components of the basal transcription machinery provides a means through which a transcription competent complex can be formed.— Weis, L.; Reinberg, D. Transcription by RNA polymerase II: initiator‐directed formation of transcription‐competent complexes. FASEB J. 6: 3300‐3309; 1992.