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Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction
Author(s) -
Levitzki Alexander
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.14.1426765
Subject(s) - signal transduction , tyrosine kinase , receptor tyrosine kinase , cancer research , kinase , protein tyrosine phosphatase , pharmacology , biology , chemistry , microbiology and biotechnology
Protein tyrosine kinases (PTKs) are members of a growing family of oncoproteins and protooncoproteins that play a pivotal role in normal and abnormal proliferative processes. This hallmark identifies these unique proteins as potential targets for antiproliferative therapy. This review discusses the current status of PTK inhibitors, with special emphasis on tyrphostins as antiproliferative agents and as potential drugs for cancers, leukemias, psoriasis, and restenosis as well as other proliferative conditions. The development of tyrphostins as selective signal blockers can be viewed as a first step toward the development of “smart” cocktails as antiproliferative agents. Each of these custom‐made cocktails will be aimed at proliferative conditions whose transduction pathways can be characterized by molecular tools. The review also discusses the use of PTK blockers as tools to study signal transduction processes in which protein tyrosine kinases are implicated.— Levitzki, A. Tyrphostines: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction FASEB J. 6: 3275‐3282; 1992.