Premium
Regulation of transferrin gene expression
Author(s) -
Zakin Mario M.
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.14.1426763
Subject(s) - transferrin , gene , gene expression , biology , regulation of gene expression , microbiology and biotechnology , genetics , biochemistry
Transferrin (Tf) is the iron‐transport protein of vertebrate serum. It is essentially synthesized in the liver, but lower amounts are also produced in other organs, such as testis and brain. A number of studies have been done to characterize the transcriptional elements implicated in the regulation of Tf gene expression in different organs. The results of these studies support the hypothesis that the Tf gene makes use of different combinations of nuclear proteins in different subsets of cells to achieve tissue‐specific expression. It is interesting to point out that this occurs in tissues arising from different embryological origin.— Zakin, M. M. Regulation of transferrin gene expression. FASEB J. 6: 3253‐3258; 1992.