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Function of the c‐Myc oncoprotein
Author(s) -
Kato Gregory J.,
Dang Chi V.
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.12.1521738
Subject(s) - carcinogenesis , phosphoprotein , oncogene , transcription factor , nuclear localization sequence , proto oncogene proteins c myc , biology , nuclear protein , microbiology and biotechnology , dna , nls , gene , transcription (linguistics) , cancer research , chemistry , cell cycle , genetics , linguistics , philosophy
The c‐Myc protein, the product of the c‐myc proto‐oncogene, is a nuclear phosphoprotein with DNA binding properties. Deregulated c‐myc expression participates in the development of experimentally induced tumors, and its expression appears to be abnormal in many naturally occurring malignancies. Although the precise molecular mechanism of c‐Myc activity in oncogenesis and in normal cell proliferation is unknown, recent advances have uncovered a series of molecular and cellular properties of c‐Myc. These properties include nuclear localization, transcriptional activation, oligomerization, nonspecific and specific DNA binding. Recently, the c‐Myc protein was found to heterodimerize with Max, a protein that cooperates with c‐Myc to bind specifically to a core DNA sequence, CAC(G/A)TG. These characteristics suggest that c‐Myc participates in the regulation of gene transcription in normal and neoplastic cells.— Kato, G. J.; Dang, C. V. Function of the c‐Myc oncoprotein. FASEB J. 6: 3065‐3072; 1992.