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Glucose and diabetic vascular disease 1
Author(s) -
Ruderman Neil B.,
Williamson Joseph R.,
Brownlee Michael
Publication year - 1992
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.6.11.1644256
Subject(s) - diabetes mellitus , vascular disease , disease , medicine , metabolic disease , carbohydrate metabolism , endocrinology , vascular smooth muscle , physiology , bioinformatics , biology , smooth muscle
The central therapeutic problem in diabetes mellitus is prevention and treatment of the chronic vascular disease associated with this disorder. Prolonged exposure to hyperglycemia is the primary factor associated with the development of diabetes‐specific microvascular disease, and the relationship between deranged glucose metabolism and arterial disease is complicated by many other factors that influence atherogenesis in non‐diabetics. Until relatively recently, knowledge about diabetic vascular disease was limited mainly to clinical description. New information about abnormal vascular physiology, ultrastructure, biochemistry, cell biology, and molecular biology now makes it possible to understand in an integrated fashion the major specific mechanisms by which hyperglycemia damages diabetic vessels. Continued progress in this area will further optimize the development of safe and effective drugs for the treatment of diabetic vascular disease.— Ruderman, N. B.; Williamson, J. R.; Brownlee, M. Glucose and diabetic vascular disease. FASEB J. 6: 2905‐2914; 1992.