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Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression
Author(s) -
Wahli Walter,
Martinez Ernest
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.9.1860615
Subject(s) - nuclear receptor , enhancer , pelp 1 , transcription factor , promoter , biology , microbiology and biotechnology , receptor , psychological repression , gene , genetics , gene expression
The nuclear hormone receptor superfamily is characterized by an impressive functional diversity of its members despite a remarkable overall structural unity. A variety of ligands bind specifically to them and these receptors control gene networks that have profound effects on growth, development, and homeostasis. The ligand‐receptor complexes recognize transcriptional enhancer DNA sequences, the hormone response elements, resulting in induction or repression of gene activity. The similarity between all these hormone response enhancer elements, as well as between the receptors themselves, indicates a conserved general strategy for the hormonal control of transcription by steroids. The activated receptors bind to responsive promoters and most likely mediate the assembly of stage‐ and tissue‐specific transcription factor complexes that stimulate or inhibit gene expression.—Wahli, W.; Martinez, E. Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression. FASEB J. 5: 2243–2249; 1991.