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The BHE rat: an animal model for the study of non‐insulin‐dependent diabetes mellitus
Author(s) -
Berdanier Carolyn D.
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.8.2022312
Subject(s) - diabetes mellitus , medicine , endocrinology , insulin , obesity , animal model
Most rodents that spontaneously develop non‐insulin‐dependent diabetes mellitus are obese. The exception is the BHE rat. This rat develops abnormal glucose tolerance by 300 days of age, is lipemic, has a fatty liver, and yet is not obese. The strain has existed for at least 40 years and almost 100 research papers have been published describing its metabolic characteristics and responses to diet manipulation. A subline that has a higher percentage of diabetic animals has been produced. These animals may be useful in the study of mild diabetes that exists in the absence of obesity.—Berdanier, C. D. The BHE rat: an animal model for the study of non‐insulin‐dependent diabetes mellitus. FASEB J. 5: 2139–2144; 1991.