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Regulation of muscle carbohydrate metabolism during exercise 1
Author(s) -
Stanley William C.,
Connett Richard J.
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.8.1827082
Subject(s) - glycogenolysis , glycolysis , phosphofructokinase , carbohydrate metabolism , biochemistry , metabolism , glycogen , chemistry , biology , microbiology and biotechnology
This review examines the mechanisms that regulate muscle carbohydrate metabolism during exercise. Muscle carbohydrate utilization is regulated primarily by two factors, namely, delivery of substrate to the glycolytic pathway either from glycogenolysis or from transport of extracellular glucose into the fibers, and formation of triosephosphate by phosphofructokinase. The regulation involves the integration of the glycolytic controls with other metabolic controls and the needs of the whole muscle in meeting the physiological demand. The controls operating in the glycolytic sequence in vivo appear to couple glycolytic recruitment to signals from the rate of energy demand, the TCA cycle state, and the mitochondrial redox state so as to satisfy the major regulatory goal of maintaining the supply of ATP for tension development.—Stanley, W. C.; Connett, R. J. Regulation of muscle carbohydrate metabolism during exercise. FASEB J. 5: 2155–2159; 1991.