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Function follows form: generation of intracellular signals by cell deformation
Author(s) -
Watson P. A.
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.7.1707019
Subject(s) - mechanotransduction , intracellular , function (biology) , chemistry , mechanobiology , biophysics , extracellular , cell function , microbiology and biotechnology , extracellular matrix , cellular adaptation , cell , biology , biochemistry , gene
Cells are exposed during their lifetimes to an array of physical forces ranging from those generated by association with other cells and extracellular matrices to the constant forces placed on cells by gravity. Alterations in these forces, either with differentiation and development or changes in activity or behavior, result in modifications in the biochemistry and adaptation in structure and function of cells. Also, a variety of differentiated cells have unique shapes that relate to extremely specialized functions, with structure and function emerging concurrently. These observations lead to the concept that the forces perceived by cells may dictate their shape, and the combined effects of external physical stimuli and internal forces responsible for maintaining cell shape may stimulate alterations in cellular biochemistry. This review examines the state of our knowledge concerning the mechanisms through which physical forces are converted to biochemical signals (mechanotransduction), and speculates on the molecular structures that may be involved in mechanotransduction.—Watson, P. A. Function follows form: generation of intracellular signals by cell deformation. FASEB J. 5: 2013–2019; 1991.